Targeting the stromal fibroblasts: a novel approach to melanoma therapy

Expert Rev Anticancer Ther. 2005 Dec;5(6):1069-78. doi: 10.1586/14737140.5.6.1069.


Classically, cancer is thought of as a genetic disease, where the step-wise acquisition of mutations initiates and drives progression. More recent thinking posits that, although cancers are initiated through genetic mutation, progression is often the result of dynamic interactions between the tumor cells and their surrounding environment.

Publication types

  • Review

MeSH terms

  • Cell Adhesion
  • Cell Communication
  • Disease Progression
  • Drug Resistance, Neoplasm
  • Fibroblasts / immunology*
  • Humans
  • Keratinocytes / physiology*
  • Melanoma / immunology*
  • Melanoma / therapy*
  • Neoplasm Invasiveness
  • Neovascularization, Pathologic
  • Phenotype
  • Skin Neoplasms / immunology*
  • Skin Neoplasms / therapy*
  • Stromal Cells
  • Transforming Growth Factor beta / physiology


  • Transforming Growth Factor beta