Autoimmune diseases: overview and current concepts of pathogenesis

Clin Biochem. 1992 Jun;25(3):181-5. doi: 10.1016/0009-9120(92)90276-x.


No single theory or mechanism can adequately explain all features or pathogenesis of autoimmune diseases. The clinically wide spectrum of autoimmune diseases is best considered as the mosaic of autoimmunity and the many factors involved are genetic, hormonal, immunological, and environmental. These multifactorial considerations help to explain not only the diversity of various clinical diseases encountered but also the differences in clinical manifestations from patient to patient within the same disease group.

Publication types

  • Review

MeSH terms

  • Autoimmune Diseases / diagnosis
  • Autoimmune Diseases / etiology*
  • Autoimmune Diseases / physiopathology
  • Humans
  • Neoplasms / immunology