Mitosis: a matter of getting rid of the right protein at the right time

Trends Cell Biol. 2006 Jan;16(1):55-63. doi: 10.1016/j.tcb.2005.11.006. Epub 2005 Dec 5.


There are two major problems for the cell to solve in mitosis: how to ensure that each daughter cell receives an equal and identical complement of the genome, and how to prevent cell separation before chromosome segregation. Both these problems are solved by controlling when two specific proteins are destroyed: securin, an inhibitor of chromosome segregation, and cyclin B, which inhibits cell separation (cytokinesis). It has recently become clear that several other proteins are degraded at specific points in mitosis. This review (which is part of the Chromosome Segregation and Aneuploidy series) focuses on how specific proteins are selected for proteolysis at defined points in mitosis and how this contributes to the proper coordination of chromosome segregation and cytokinesis.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Anaphase-Promoting Complex-Cyclosome
  • Animals
  • Cell Cycle Proteins / physiology*
  • Chromosome Segregation / physiology*
  • Cyclin B / physiology
  • Cytokinesis / physiology*
  • Gene Expression Regulation
  • Genes, cdc / physiology
  • Humans
  • Mitosis / physiology*
  • Peptide Hydrolases / physiology
  • Time Factors
  • Ubiquitin / physiology
  • Ubiquitin-Protein Ligase Complexes / physiology


  • Cell Cycle Proteins
  • Cyclin B
  • Ubiquitin
  • Ubiquitin-Protein Ligase Complexes
  • Anaphase-Promoting Complex-Cyclosome
  • Peptide Hydrolases