Therapeutic effects of hidrosmin on chronic venous insufficiency of the lower limbs

Curr Med Res Opin. 1992;12(10):623-30. doi: 10.1185/03007999209111529.


A double-blind, placebo-controlled trial was carried out to assess the effectiveness of a new synthetic bioflavonoid, hidrosmin, in patients with chronic venous insufficiency of the lower limbs. Fifty-seven patients, showing varicose veins and ankle swelling and suffering from local pain and heaviness of the legs, were allocated at random to receive treatment for 45 days with 1 capsule 3-times daily of either 200 mg hidrosmin (30 patients) or placebo (27 patients). Pain and heavy legs were assessed using rating scales; swelling was assessed by a photographic method. The results showed that hidrosmin produced a significant clinical improvement in all of the parameters evaluated; compared with placebo, there was a marked reduction in the main subjective symptoms accompanied by a 10% reduction in swelling. Apart from 1 patient who complained of epigastric pain, there were no reports of adverse events during the study period.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Aged
  • Chronic Disease
  • Diosmin / analogs & derivatives*
  • Diosmin / therapeutic use
  • Double-Blind Method
  • Edema / drug therapy
  • Female
  • Humans
  • Male
  • Middle Aged
  • Venous Insufficiency / drug therapy*


  • hidrosmin
  • Diosmin