Colony-stimulating factor-1 in Immunity and Inflammation

Curr Opin Immunol. 2006 Feb;18(1):39-48. doi: 10.1016/j.coi.2005.11.006. Epub 2005 Dec 6.

Abstract

Colony-stimulating factor-1 (CSF-1, also known as macrophage-CSF) is the primary regulator of the survival, proliferation, differentiation and function of mononuclear phagocytes. Studies that involve CSF-1-deficient mice demonstrate that there is a variable requirement for CSF-1 in the development of individual mononuclear phagocyte populations. However, these cells uniformly express the CSF-1 receptor, and their morphology, phagocytosis and responsiveness to infectious and non-infectious stimuli is regulated by CSF-1. CSF-1 plays important roles in innate immunity, cancer and inflammatory diseases, including systemic lupus erythematosus, arthritis, atherosclerosis and obesity. In several conditions, activation of macrophages involves a CSF-1 autocrine loop. In addition, secreted and cell-surface isoforms of CSF-1 can have differential effects in inflammation and immunity.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Humans
  • Inflammation / immunology*
  • Macrophage Activation / immunology
  • Macrophage Colony-Stimulating Factor / physiology*
  • Phagocytes / immunology*

Substances

  • Macrophage Colony-Stimulating Factor