From A to Z and back? Multicompartment proteins in the sarcomere

Trends Cell Biol. 2006 Jan;16(1):11-8. doi: 10.1016/j.tcb.2005.11.007. Epub 2005 Dec 6.


Sarcomeres, the smallest contractile units of striated muscle, are conventionally perceived as the most regular macromolecular assemblies in biology, with precisely assigned localizations for their constituent proteins. However, recent studies have revealed complex multiple locations for several sarcomere proteins within the sarcomere and other cellular compartments such as the nucleus. Several of these proteins appear to relocalize in response to mechanical stimuli. Here, we review the emerging role of these protein networks as dynamic information switchboards that communicate between the contractile machinery and the nucleus to central pathways controlling cell survival, protein breakdown, gene expression and extracellular signaling.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Nucleus / chemistry
  • Cell Survival
  • Connectin
  • Cytoskeletal Proteins / analysis
  • Cytoskeletal Proteins / physiology
  • Gene Expression Regulation
  • Humans
  • Muscle Proteins / analysis*
  • Muscle Proteins / metabolism
  • Muscle Proteins / physiology*
  • Protein Kinases / metabolism
  • Protein Processing, Post-Translational
  • Sarcomeres / chemistry*
  • Sarcomeres / physiology
  • Sarcomeres / ultrastructure
  • Signal Transduction


  • Connectin
  • Cytoskeletal Proteins
  • Muscle Proteins
  • TTN protein, human
  • Protein Kinases