The structures of MsbA: Insight into ABC transporter-mediated multidrug efflux

FEBS Lett. 2006 Feb 13;580(4):1042-8. doi: 10.1016/j.febslet.2005.11.033. Epub 2005 Dec 1.


ATP-binding cassette (ABC) transporters are integral membrane proteins that couple ATP hydrolysis to the transport of various molecules across cellular membranes. Found in both prokaryotes and eukaryotes, a sub-group of these transporters are involved in the efflux of hydrophobic drugs and lipids, causing anti-microbial and chemotherapeutic multidrug resistance. In this review, we examine recent structural and functional analysis of the ABC transporter MsbA and implications on the mechanism of multidrug efflux.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • ATP-Binding Cassette Transporters / chemistry
  • ATP-Binding Cassette Transporters / physiology*
  • Adenosine Triphosphate / metabolism
  • Bacterial Proteins / chemistry*
  • Bacterial Proteins / physiology*
  • Crystallography, X-Ray
  • Hydrolysis
  • Pharmacokinetics*
  • Protein Conformation
  • Protein Transport
  • Substrate Specificity


  • ATP-Binding Cassette Transporters
  • Bacterial Proteins
  • MsbA protein, Bacteria
  • Adenosine Triphosphate