Aurora-A overexpression associates with Ha-ras codon-12 mutation and blackfoot disease endemic area in bladder cancer

Cancer Lett. 2006 Sep 8;241(1):93-101. doi: 10.1016/j.canlet.2005.10.014. Epub 2005 Dec 9.


Our data revealed that 59.4% of the bladder cancer specimens showed Aurora-A overexpression, of which 31.8% also had Ha-ras codon-12 mutation; 45.5% were from blackfoot-disease endemic areas in which arsenic exposure is a major environment factor associated with various cancer formation. We further demonstrated that arsenic treatment of the immortalized bladder cell line, E7, increased Aurora-A expression. All together, co-existence of Aurora-A overexpression and Ha-ras mutation suggests a possible additively effect on the tumorigenesis of bladder cancer. In addition, Aurora-A overexpression and up-regulated by arsenic exposure opens a new direction for exploring the occurrence of bladder cancer occurrence in Taiwan.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arsenic / toxicity
  • Aurora Kinases
  • Cell Line, Tumor
  • Cell Transformation, Neoplastic
  • Codon*
  • Endemic Diseases
  • Genes, ras*
  • Humans
  • Mutation*
  • Peripheral Vascular Diseases / epidemiology
  • Peripheral Vascular Diseases / genetics*
  • Polymorphism, Single Nucleotide
  • Protein Serine-Threonine Kinases / genetics*
  • RNA, Messenger / genetics


  • Codon
  • RNA, Messenger
  • Aurora Kinases
  • Protein Serine-Threonine Kinases
  • Arsenic