Expression of c-fos, c-jun, jun-B, metallothionein and metalloproteinase genes in human chondrocyte

FEBS Lett. 1992 Jul 20;306(2-3):169-72. doi: 10.1016/0014-5793(92)80992-p.


Normal and osteoarthritic (OA) human articular cartilage chondrocytes, released enzymatically in the presence of 0.5% fetal calf serum, display constitutive expression of early response activating protein (AP-1) genes; c-fos, c-jun and jun-B. Among the late AP-1 responsive genes, total metallothionein (MT) and stromelysin mRNAs were expressed at high levels in both normal and OA chondrocytes, while collagenase and hMT-IIA mRNA levels were elevated only in OA individuals. Despite the common AP-1 sequences present in their promoter regions, the three late genes were differentially expressed.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Blotting, Northern
  • Cartilage / cytology
  • Cartilage / metabolism*
  • DNA-Binding Proteins / genetics*
  • Female
  • Gene Expression
  • Humans
  • Male
  • Metalloendopeptidases / genetics*
  • Metallothionein / genetics*
  • Osteoarthritis / metabolism
  • Proto-Oncogene Proteins c-fos / genetics*
  • Proto-Oncogene Proteins c-jun / genetics*


  • DNA-Binding Proteins
  • Proto-Oncogene Proteins c-fos
  • Proto-Oncogene Proteins c-jun
  • Metallothionein
  • Metalloendopeptidases