Microbiology profile in women with pelvic inflammatory disease in relation to IUD use

Infect Dis Obstet Gynecol. 2005 Dec;13(4):183-90. doi: 10.1080/10647440500097601.


Objective: To study the microbial characteristics of patients with pelvic inflammatory disease (PID) and the possible impact of an intrauterine device (IUD) on the microbial environment in women presenting with PID.

Methods: Case-control study, investigating 51 women with acute PID and 50 healthy women. Endocervical specimens for microbiological investigation were obtained at gynaecological examination.

Results: IUD users with PID had significantly more Fusobacteria spp. and Peptostreptococcus spp. than non-IUD users with PID. The finding of combinations of several anaerobic or aerobic microbes was associated with a significantly increased risk of PID and with complicated PID. In IUD users, the combinations of several anaerobic/aerobic microbes were associated with an increased risk of PID, irrespective of duration of IUD use. Long-term IUD use appeared to be associated with an increased risk of a PID being complicated.

Conclusion: The finding of several anaerobic or aerobic microbes appears to be associated with PID in users of IUD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Female
  • Humans
  • Intrauterine Devices / adverse effects*
  • Pelvic Inflammatory Disease / epidemiology
  • Pelvic Inflammatory Disease / etiology
  • Pelvic Inflammatory Disease / microbiology*
  • Surveys and Questionnaires
  • Women's Health