Cytochrome c oxidase deficiency in a child with isolated myopathy

Fetal Pediatr Pathol. May-Jun 2005;24(3):149-53. doi: 10.1080/15227950500304218.


Cytochrome c oxidase (COX) deficiency is the most commonly recognized respiratory chain defect in childhood. The disease is clinically heterogeneous with phenotypes including Leigh syndrome, hepatic failure and myopathies. COX deficiency has been associated with mitochondrial DNA mutations in COX I, II, and III with large-scale deletions of the mitochondrial genome and with point mutations in mitochondrial tRNA genes. Here we report on a 3.5-year-old girl with a rare type of isolated myopathy due to COX deficiency.

Publication types

  • Case Reports

MeSH terms

  • Child, Preschool
  • Cytochrome-c Oxidase Deficiency / complications
  • Cytochrome-c Oxidase Deficiency / drug therapy
  • Cytochrome-c Oxidase Deficiency / pathology*
  • Female
  • Humans
  • Muscle Hypotonia / drug therapy
  • Muscle Hypotonia / etiology
  • Muscle Hypotonia / pathology
  • Ubiquinone / therapeutic use


  • Ubiquinone