Bupropion may improve restless legs syndrome: a report of three cases

Clin Neuropharmacol. Nov-Dec 2005;28(6):298-301. doi: 10.1097/01.wnf.0000194706.61224.29.


Restless legs syndrome (RLS) is a common disorder for which agents that enhance dopaminergic activity, including dopamine agonists and levodopa, are the treatment of choice. However, long-term use of dopaminergic drugs can cause unwanted effects such as rebound, tolerance, and augmentation. Bupropion, an inhibitor of dopamine and noradrenalin reuptake, is an antidepressant that modulates dopaminergic systems. The authors report that a low dose of bupropion rapidly and completely ameliorated RLS symptoms in 3 depressed patients within a few days of the initiation of treatment. To their knowledge, this is the first report to show that bupropion may be an effective alternative for treating RLS. Consequently, bupropion may be useful for the treatment of patients with both depression and RLS.

Publication types

  • Case Reports
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Antidepressive Agents, Second-Generation / therapeutic use*
  • Bupropion / therapeutic use*
  • Demography
  • Female
  • Humans
  • Middle Aged
  • Restless Legs Syndrome / drug therapy*
  • Treatment Outcome


  • Antidepressive Agents, Second-Generation
  • Bupropion