Styrene and ischemic heart disease mortality among synthetic rubber industry workers

J Occup Environ Med. 2005 Dec;47(12):1235-43. doi: 10.1097/


Objective: We examined the relation between styrene and ischemic heart disease (IHD) mortality among 16,579 men in the synthetic rubber industry.

Methods: Associations were measured using stratified and multivariable analysis.

Results: Compared with workers with no exposure to styrene, men in the highest quintile of average intensity of exposure (5.50+ parts per million [ppm]) and in the highest quintile of cumulative exposure (60.67+ ppm-years) had IHD rate ratios of 1.14 (95% confidence interval [CI]=0.96-1.35) and 1.07 (95% CI=0.90-1.27), respectively. Acute IHD was not associated with average intensity of exposure within the most recent 2 years or with other indices of exposure. Chronic IHD rates were elevated in subjects with the highest exposure; these associations were weak and imprecise, and evidence of a positive exposure-response relation was limited.

Conclusion: This study does not indicate that exposure to styrene causes fatal IHD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Canada
  • Humans
  • Industry
  • Male
  • Middle Aged
  • Multivariate Analysis
  • Myocardial Ischemia / mortality*
  • Occupational Exposure
  • Rubber*
  • Styrene / adverse effects*
  • United States / epidemiology


  • Styrene
  • Rubber