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Comparative Study
, 438 (7069), 803-19

Genome Sequence, Comparative Analysis and Haplotype Structure of the Domestic Dog

Kerstin Lindblad-Toh  1 Claire M WadeTarjei S MikkelsenElinor K KarlssonDavid B JaffeMichael KamalMichele ClampJean L ChangEdward J Kulbokas 3rdMichael C ZodyEvan MauceliXiaohui XieMatthew BreenRobert K WayneElaine A OstranderChris P PontingFrancis GalibertDouglas R SmithPieter J DeJongEwen KirknessPablo AlvarezTara BiagiWilliam BrockmanJonathan ButlerChee-Wye ChinApril CookJames CuffMark J DalyDavid DeCaprioSante GnerreManfred GrabherrManolis KellisMichael KleberCarolyne BardelebenLeo GoodstadtAndreas HegerChristophe HitteLisa KimKlaus-Peter KoepfliHeidi G ParkerJohn P PollingerStephen M J SearleNathan B SutterRachael ThomasCaleb WebberJennifer BaldwinAdal AbebeAmr AbouelleilLynne AftuckMostafa Ait-ZahraTyler AldredgeNicole AllenPeter AnScott AndersonClaudel AntoineHarindra ArachchiAli AslamLaura AyottePasang BachantsangAndrew BarryTashi BayulMostafa BenamaraAaron BerlinDaniel BessetteBerta BlitshteynToby BloomJason BlyeLeonid BoguslavskiyClaude BonnetBoris BoukhgalterAdam BrownPatrick CahillNadia CalixteJody CamarataYama CheshatsangJeffrey ChuMieke CitroenAlville CollymorePatrick CookeTenzin DawoeRiza DazaKarin DecktorStuart DeGrayNorbu DhargayKimberly DooleyKathleen DooleyPassang DorjeKunsang DorjeeLester DorrisNoah DuffeyAlan DupesOsebhajajeme EgbiremolenRichard ElongJill FalkAbderrahim FarinaSusan FaroDiallo FergusonPatricia FerreiraSheila FisherMike FitzGeraldKaren FoleyChelsea FoleyAlicia FrankeDennis FriedrichDiane GageManuel GarberGary GearinGeorgia GiannoukosTina GoodeAudra GoyetteJoseph GrahamEdward GrandboisKunsang GyaltsenNabil HafezDaniel HagopianBirhane HagosJennifer HallClaire HealyRyan HegartyTracey HonanAndrea HornNathan HoudeLeanne HughesLeigh HunnicuttM HusbyBenjamin JesterCharlien JonesAsha KamatBen KangaCristyn KellsDmitry KhazanovichAlix Chinh KieuPeter KisnerMayank KumarKrista LanceThomas LandersMarcia LaraWilliam LeeJean-Pierre LegerNiall LennonLisa LeuperSarah LeVineJinlei LiuXiaohong LiuYeshi LokyitsangTashi LokyitsangAnnie LuiJan MacdonaldJohn MajorRichard MarabellaKebede MaruCharles MatthewsSusan McDonoughTeena MehtaJames MeldrimAlexandre MelnikovLouis MeneusAtanas MihalevTanya MihovaKaren MillerRachel MittelmanValentine MlengaLeonidas MulrainGlen MunsonAdam NavidiJerome NaylorTuyen NguyenNga NguyenCindy NguyenThu NguyenRobert NicolNyima NorbuChoe NorbuNathaniel NovodTenchoe NyimaPeter OlandtBarry O'NeillKeith O'NeillSahal OsmanLucien OyonoChristopher PattiDanielle PerrinPema PhunkhangFritz PierreMargaret PriestAnthony RachupkaSujaa RaghuramanRayale RameauVerneda RayChristina RaymondFilip RegeCecil RiseJulie RogersPeter RogovJulie SahalieSampath SettipalliTheodore SharpeTerrance SheaMechele SheehanNgawang SherpaJianying ShiDiana ShihJessie SloanCherylyn SmithTodd SparrowJohn StalkerNicole Stange-ThomannSharon StavropoulosCatherine StoneSabrina StoneSean SykesPierre TchuingaPema TenzingSenait TesfayeDawa ThoulutsangYama ThoulutsangKerri TophamIra ToppingTsamla TsamlaHelen VassilievVijay VenkataramanAndy VoTsering WangchukTsering WangdiMichael WeiandJane WilkinsonAdam WilsonShailendra YadavShuli YangXiaoping YangGeneva YoungQing YuJoanne ZainounLisa ZembekAndrew ZimmerEric S Lander
Affiliations
Comparative Study

Genome Sequence, Comparative Analysis and Haplotype Structure of the Domestic Dog

Kerstin Lindblad-Toh et al. Nature.

Abstract

Here we report a high-quality draft genome sequence of the domestic dog (Canis familiaris), together with a dense map of single nucleotide polymorphisms (SNPs) across breeds. The dog is of particular interest because it provides important evolutionary information and because existing breeds show great phenotypic diversity for morphological, physiological and behavioural traits. We use sequence comparison with the primate and rodent lineages to shed light on the structure and evolution of genomes and genes. Notably, the majority of the most highly conserved non-coding sequences in mammalian genomes are clustered near a small subset of genes with important roles in development. Analysis of SNPs reveals long-range haplotypes across the entire dog genome, and defines the nature of genetic diversity within and across breeds. The current SNP map now makes it possible for genome-wide association studies to identify genes responsible for diseases and traits, with important consequences for human and companion animal health.

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