Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 6 (12), 893-904

Modulating Hox Gene Functions During Animal Body Patterning


Modulating Hox Gene Functions During Animal Body Patterning

Joseph C Pearson et al. Nat Rev Genet.


With their power to shape animal morphology, few genes have captured the imagination of biologists as the evolutionarily conserved members of the Hox clusters have done. Recent research has provided new insight into how Hox proteins cause morphological diversity at the organismal and evolutionary levels. Furthermore, an expanding collection of sequences that are directly regulated by Hox proteins provides information on the specificity of target-gene activation, which might allow the successful prediction of novel Hox-response genes. Finally, the recent discovery of microRNA genes within the Hox gene clusters indicates yet another level of control by Hox genes in development and evolution.

Similar articles

See all similar articles

Cited by 304 articles

See all "Cited by" articles

Publication types

MeSH terms

LinkOut - more resources