Oncogenic PI3K deregulates transcription and translation

Nat Rev Cancer. 2005 Dec;5(12):921-9. doi: 10.1038/nrc1753.


There have long been indications of a role for PI3K (phosphatidylinositol 3-kinase) in cancer pathogenesis. Experimental data document a requirement for deregulation of both transcription and translation in PI3K-mediated oncogenic transformation. The recent discoveries of cancer-specific mutations in PIK3CA, the gene that encodes the catalytic subunit p110alpha of PI3K, have heightened the interest in the oncogenic potential of this lipid kinase and have made p110alpha an ideal drug target.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Catalytic Domain
  • Forkhead Transcription Factors / genetics
  • Humans
  • Mutation
  • Neoplasms / enzymology*
  • Neoplasms / genetics
  • Phosphatidylinositol 3-Kinases / genetics*
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Biosynthesis
  • Protein Sorting Signals / genetics
  • Transcription, Genetic


  • Forkhead Transcription Factors
  • Phosphoinositide-3 Kinase Inhibitors
  • Protein Sorting Signals