Iontophoresis: a non-invasive ocular drug delivery

J Control Release. 2006 Feb 21;110(3):479-89. doi: 10.1016/j.jconrel.2005.09.049. Epub 2005 Dec 15.


Iontophoresis as a non-invasive technique for ocular drug delivery has been investigated for many years. This paper provides an overview of the approaches currently used in the development of the ocular iontophoretic device, the essential features of this procedure and the reported toxicity. This review focuses on the experimental results after transcorneal and transscleral iontophoresis of different drugs, emphasizing the current density applied and the treatment duration used by the investigators.

Publication types

  • Review

MeSH terms

  • Administration, Topical
  • Animals
  • Drug Delivery Systems / methods*
  • Eye / drug effects
  • Eye / metabolism*
  • Eye Diseases / drug therapy
  • Eye Diseases / metabolism
  • Humans
  • Iontophoresis / methods*