Protein complexes regulating Arp2/3-mediated actin assembly

Curr Opin Cell Biol. 2006 Feb;18(1):4-10. doi: 10.1016/ Epub 2005 Dec 15.


Key steps in regulating actin dynamics are the de novo nucleation and elongation of actin filaments, which can be catalysed by a limited number of proteins and protein complexes. Among these, Arp2/3 complex and formins are the best studied. Arp2/3-complex activity is controlled through signalling-dependent association with nucleation-promoting factors, such as the WASP/WAVE family proteins. A common theme for these molecules, which is well established for WAVEs but is only just beginning to emerge for WASPs, is that they act as coincident detectors of a variety of signalling pathways through the formation of large multi-molecular complexes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Actin-Related Protein 2-3 Complex / metabolism
  • Actin-Related Protein 2-3 Complex / physiology*
  • Actins / metabolism*
  • Adaptor Proteins, Signal Transducing / physiology
  • Animals
  • Biopolymers
  • Cell Surface Extensions / metabolism
  • Models, Biological
  • Signal Transduction
  • Wiskott-Aldrich Syndrome Protein Family / metabolism
  • Wiskott-Aldrich Syndrome Protein Family / physiology*


  • Actin-Related Protein 2-3 Complex
  • Actins
  • Adaptor Proteins, Signal Transducing
  • Biopolymers
  • Wiskott-Aldrich Syndrome Protein Family