Vacancy engineered ceria nanostructures for protection from radiation-induced cellular damage

Nano Lett. 2005 Dec;5(12):2573-7. doi: 10.1021/nl052024f.

Abstract

The ability of engineered cerium oxide nanoparticles to confer radioprotection was examined. Human normal and tumor cells were treated with nanoceria and irradiated, and cell survival was measured. Treatment of normal cells conferred almost 99% protection from radiation-induced cell death, whereas the same concentration showed almost no protection of tumor cells. For the first time, nanoceria is shown to confer radioprotection to a normal human breast line but not to a human breast tumor line, MCF-7.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apoptosis / drug effects
  • Apoptosis / radiation effects
  • Biomedical Engineering / methods
  • Breast / cytology
  • Breast / drug effects*
  • Breast / radiation effects*
  • Breast Neoplasms / pathology*
  • Cerium / administration & dosage*
  • Cerium / chemistry*
  • Chemistry, Pharmaceutical / methods
  • Dosage Forms
  • Dose-Response Relationship, Radiation
  • Humans
  • Nanostructures / chemistry*
  • Nanostructures / ultrastructure
  • Particle Size
  • Radiation Dosage
  • Radiation Protection / methods*
  • Radiation Tolerance / drug effects
  • Tumor Cells, Cultured

Substances

  • Dosage Forms
  • Cerium
  • ceric oxide