Platelet transfusion prophylaxis for patients with haematological malignancies: where to now?

Br J Haematol. 2005 Dec;131(5):588-95. doi: 10.1111/j.1365-2141.2005.05769.x.


National guidelines for platelet transfusion in many countries recommend that the general platelet transfusion trigger for prophylaxis is 10x10(9)/l. This annotation reviews the evidence for this threshold level and discusses other current unresolved issues relevant to platelet transfusion practice such as the optimal dose and the clinical benefit of a strategy for the prophylactic use of platelet transfusions when the platelet count falls below a given threshold.

Publication types

  • Review

MeSH terms

  • Guideline Adherence
  • Hematologic Neoplasms / complications
  • Hematologic Neoplasms / therapy*
  • Hemorrhage / etiology
  • Hemorrhage / therapy*
  • Humans
  • Patient Selection*
  • Platelet Transfusion / methods*
  • Randomized Controlled Trials as Topic
  • Thrombocytopenia / etiology
  • Thrombocytopenia / prevention & control
  • Thrombocytopenia / therapy*