Assessment of compliance with lipid guidelines in an academic medical center

Ann Pharmacother. 2006 Jan;40(1):27-31. doi: 10.1345/aph.1G303. Epub 2005 Dec 13.

Abstract

Background: The importance of achieving a low-density lipoprotein cholesterol (LDL-C) level less than 100 mg/dL in patients with coronary artery disease (CAD) or cerebrovascular disease (CVD) is well established. Emerging evidence supports the recognition and management of secondary lipid goals, high-density lipoprotein cholesterol (HDL-C) level greater than 40 mg/dL, and triglyceride level less than 150 mg/dL.

Objective: To evaluate whether inpatient services within an academic setting were achieving/addressing primary and secondary lipid goals in patients with established CAD or CVD.

Methods: Patients with a discharge diagnosis of acute myocardial infarction, myocardial revascularization procedures, and/or ischemic stroke were identified. A retrospective chart review was done to assess adherence to the American Heart Association (AHA)/American College of Cardiology (ACC) guidelines for lipid management.

Results: On average, 63% of patients with CAD or CVD had a lipid panel assessed during their hospitalization. Of the patients who had a fasting lipid panel checked, only 40% (72/178) had an LDL-C level less than 100 mg/dL. Of those patients, only 31% (22) also had an HDL-C level greater than 40 mg/dL. Even fewer patients (24%; 17) met both primary and secondary goals. Of the 287 patients included in the study, 69% (199) were prescribed a statin, 3% (9) a fibrate, and 3% (8) niacin on discharge.

Conclusions: Few patients with CAD or CVD met the AHA/ACC goals for lipid management, yet a significant number were not prescribed appropriate lipid-lowering therapy at discharge. This finding strongly suggests that more awareness in this area is needed.

MeSH terms

  • Academic Medical Centers*
  • American Heart Association
  • Angioplasty, Balloon, Coronary
  • Cerebrovascular Disorders / blood
  • Cerebrovascular Disorders / therapy
  • Cholesterol, LDL / blood*
  • Cholesterol, LDL / standards
  • Clofibric Acid / therapeutic use
  • Coronary Artery Bypass
  • Coronary Artery Disease / blood
  • Coronary Artery Disease / therapy
  • Guideline Adherence / standards*
  • Humans
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use
  • Hypolipidemic Agents / therapeutic use
  • Inpatients / statistics & numerical data
  • Myocardial Infarction / blood
  • Myocardial Infarction / therapy
  • Niacin / therapeutic use
  • Practice Guidelines as Topic / standards*
  • Retrospective Studies
  • Societies, Medical / organization & administration
  • Societies, Medical / standards
  • Treatment Outcome
  • United States

Substances

  • Cholesterol, LDL
  • Hydroxymethylglutaryl-CoA Reductase Inhibitors
  • Hypolipidemic Agents
  • Niacin
  • Clofibric Acid