Is cigarette smoking a risk factor for non-Hodgkin's lymphoma or multiple myeloma? Results from the Lutheran Brotherhood Cohort Study

Leuk Res. Jun-Jul 1992;16(6-7):621-4. doi: 10.1016/0145-2126(92)90011-u.


Among 17,633 U.S. white male insurance policy holders whose use of tobacco was characterized in a 1966 self-administered questionnaire, there were 49 deaths from non-Hodgkin's lymphoma (NHL) and 21 from multiple myeloma (MM) during a 20-year follow-up. Men who had ever smoked cigarettes had an elevated mortality from NHL (RR = 2.1; CI = 0.9-4.9), with risk almost four-fold greater among the heaviest smokers (RR = 3.8; CI = 1.4-10.1) compared with those who used no tobacco. In contrast, risk of MM was only slightly elevated among those who had ever smoked cigarettes (RR = 1.3; CI = 0.4-3.9) and without evidence of a dose-response trend. Since this is the first cohort study suggesting a link between cigarette smoking and NHL and findings from case-control studies have been inconsistent, additional clarification should be sought from larger incidence-based cohort investigations.

MeSH terms

  • Adult
  • Aged
  • Cohort Studies
  • Follow-Up Studies
  • Humans
  • Lymphoma, Non-Hodgkin / epidemiology*
  • Lymphoma, Non-Hodgkin / mortality
  • Male
  • Middle Aged
  • Multiple Myeloma / epidemiology*
  • Multiple Myeloma / mortality
  • Prospective Studies
  • Risk Factors
  • Smoking / adverse effects*
  • United States / epidemiology