Lymphangiogenesis in development and human disease

Nature. 2005 Dec 15;438(7070):946-53. doi: 10.1038/nature04480.


The lymphatic vasculature forms a vessel network that drains interstitial fluid from tissues and returns it to the blood. Lymphatic vessels are also an essential part of the body's immune defence. They have an important role in the pathogenesis of several diseases, such as cancer, lymphoedema and various inflammatory conditions. Recent biological and technological developments in lymphatic vascular biology will lead to a better understanding and treatment of these diseases.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Disease*
  • Endothelial Cells / drug effects
  • Endothelial Cells / metabolism
  • Humans
  • Inflammation / physiopathology
  • Lymphangiogenesis / drug effects
  • Lymphangiogenesis / physiology*
  • Lymphatic Metastasis
  • Lymphatic Vessels / cytology
  • Lymphatic Vessels / drug effects
  • Lymphatic Vessels / pathology
  • Lymphatic Vessels / physiology