Angiogenesis as a Therapeutic Target

Nature. 2005 Dec 15;438(7070):967-74. doi: 10.1038/nature04483.

Abstract

Inhibiting angiogenesis is a promising strategy for treatment of cancer and several other disorders, including age-related macular degeneration. Major progress towards a treatment has been achieved over the past few years, and the first antiangiogenic agents have been recently approved for use in several countries. Therapeutic angiogenesis (promoting new vessel growth to treat ischaemic disorders) is an exciting frontier of cardiovascular medicine, but further understanding of the mechanisms of vascular morphogenesis is needed first.

Publication types

  • Review

MeSH terms

  • Angiogenesis Inhibitors / administration & dosage
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Bone Marrow Cells / cytology
  • Bone Marrow Cells / physiology
  • Clinical Trials as Topic
  • Drug Resistance, Neoplasm
  • Humans
  • Neoplasms / blood supply*
  • Neoplasms / drug therapy*
  • Neoplasms / pathology
  • Neovascularization, Pathologic / drug therapy*
  • Signal Transduction / drug effects

Substances

  • Angiogenesis Inhibitors