A fatal intoxication following the ingestion of 5-methoxy-N,N-dimethyltryptamine in an ayahuasca preparation

J Anal Toxicol. Nov-Dec 2005;29(8):838-41. doi: 10.1093/jat/29.8.838.

Abstract

A case of a 25-year-old white male who was found dead the morning after consuming herbal extracts containing beta-carbolines and hallucinogenic tryptamines is presented. No anatomic cause of death was found at autopsy. Toxicologic analysis of the heart blood identified N,N-dimethyltryptamine (0.02 mg/L), 5-methoxy-N,N-dimethyltryptamine (1.88 mg/L), tetrahydroharmine (0.38 mg/L), harmaline (0.07 mg/L), and harmine (0.17 mg/L). All substances were extracted by a single-step n-butyl chloride extraction following alkalinization with borate buffer. Detection and quantitation was performed using liquid chromatography-electrospray mass spectrometry. The medical examiner ruled that the cause of death was hallucinogenic amine intoxication, and the manner of death was undetermined.

Publication types

  • Case Reports
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Banisteriopsis / poisoning*
  • Chromatography, Liquid
  • Fatal Outcome
  • Humans
  • Male
  • Mass Spectrometry
  • Methoxydimethyltryptamines / blood
  • Methoxydimethyltryptamines / poisoning*

Substances

  • Methoxydimethyltryptamines