Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo

Cancer Lett. 2006 Jan 8;231(1):113-22. doi: 10.1016/j.canlet.2005.01.031.


Resveratrol, a polyphenol found in grapes and wine, is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription via both ERalpha and ERbeta. We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERalpha- ERbeta+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls. In vitro we found a significant increase in apoptosis in resveratrol-treated MDA-MB-231 cells in addition to significantly reduced extracellular levels of VEGF. This study supports the potential use of resveratrol as a chemotherapeutic agent in breast cancers.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / drug therapy
  • Adenocarcinoma / pathology
  • Adenocarcinoma / prevention & control*
  • Animals
  • Anticarcinogenic Agents / pharmacology*
  • Apoptosis / drug effects*
  • Breast Neoplasms / drug therapy
  • Breast Neoplasms / pathology
  • Breast Neoplasms / prevention & control*
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Female
  • Humans
  • Mice
  • Mice, Nude
  • Neovascularization, Pathologic*
  • Resveratrol
  • Stilbenes / pharmacology*
  • Transplantation, Heterologous
  • Vascular Endothelial Growth Factor A / biosynthesis


  • Anticarcinogenic Agents
  • Estrogen Receptor alpha
  • Estrogen Receptor beta
  • Stilbenes
  • Vascular Endothelial Growth Factor A
  • Resveratrol