Antilithiatic effect of Asparagus racemosus Willd on ethylene glycol-induced lithiasis in male albino Wistar rats

Methods Find Exp Clin Pharmacol. 2005 Nov;27(9):633-8. doi: 10.1358/mf.2005.27.9.939338.


The ethanolic extract of Asparagus racemosus Willd. was evaluated for its inhibitory potential on lithiasis (stone formation), induced by oral administration of 0.75% ethylene glycolated water to adult male albino Wistar rats for 28 days. The ionic chemistry of urine was altered by ethylene glycol, which elevated the urinary concentration of crucial ions viz. calcium, oxalate, and phosphate, thereby contributing to renal stone formation. The ethanolic extract, however, significantly (p < 0.05) reduced the elevated level of these ions in urine. Also, it elevated the urinary concentration of magnesium, which is considered as one of the inhibitors of crystallization. The high serum creatinine level observed in ethylene glycol-treated rats was also reduced, following treatment with the extract. The histopathological findings also showed signs of improvement after treatment with the extract. All these observations provided the basis for the conclusion that this plant extract inhibits stone formation induced by ethylene glycol treatment.

MeSH terms

  • Animals
  • Asparagus Plant / chemistry*
  • Calcium / urine
  • Creatinine / blood
  • Ethylene Glycol
  • Kidney / drug effects*
  • Kidney / metabolism
  • Kidney / pathology
  • Kidney Calculi / chemically induced
  • Kidney Calculi / drug therapy*
  • Kidney Calculi / metabolism
  • Magnesium / urine
  • Male
  • Oxalates / urine
  • Phosphates / urine
  • Plant Extracts / pharmacology
  • Plant Roots / chemistry
  • Rats
  • Rats, Wistar


  • Oxalates
  • Phosphates
  • Plant Extracts
  • Creatinine
  • Ethylene Glycol
  • Magnesium
  • Calcium