[Genetic analysis of the predisposition to audiogenic seizure fits in Krushinsky-Molodkina rat strain]

Genetika. 2005 Nov;41(11):1487-94.
[Article in Russian]


The expression of audiogenic seizure fits has been studied in F1 hybrids between audiogenic seizure-prone Krushinsky-Molodkina rat strain and Wistar rats not prone to audiogenic seizures, as well as in two backcross generations. Only 10% of F1 hybrids exhibit audiogenic seizure fits, whereas the frequency of this character in two generations of their backcrosses with Krushinsky-Molodkina rats is about 50%. A digenic model with incomplete penetrance has been put forward to explain the control of audiogenic seizure fits. This model fits the data obtained: the theoretically expected distributions of the character in offsprings of different crosses do not differ significantly from those observed in experiments. The model explains why the distribution of the character is the same in the first and second backcross offsprings.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Crosses, Genetic*
  • Epilepsy, Reflex / genetics*
  • Female
  • Male
  • Models, Genetic*
  • Rats
  • Rats, Wistar