[Immunological and clinical study on therapeutic efficacy of inosine pranobex]

Pol Merkur Lekarski. 2005 Sep;19(111):379-82.
[Article in Polish]


Many studies in vitro and in vivo have shown immunomodulating and antiviral activities of inosine pranobex. The object of this research was to examine the potential beneficial effects of inosine pranobex (Groprinosin) on immune system in children with cellular immunodeficiency as a prophylaxis of recurrent infections, mainly of viral origin. 50 mg/kg b.w/day of inosine pranobex in divided doses was given to the group of 30 children aged 3-15 years for 10 days in 3 following months. Clinical and immunological investigations were done before and after the treatment. Statistically significant rise of CD3T lymphocytes number (p = 0.02) and in this CD4T lymphocytes number (p = 0.02) as well as statistically significant improvement of their function (p = 0.005) evaluated with blastic transformation method were found. These laboratory findings were parallel to clinical benefits. Control study was performed in the group of children completed by randomization and treated in the same way with garlic (Alliofil).

Publication types

  • Randomized Controlled Trial

MeSH terms

  • Adjuvants, Immunologic / administration & dosage
  • Adjuvants, Immunologic / therapeutic use*
  • Adolescent
  • Allium
  • Antiviral Agents / administration & dosage
  • Antiviral Agents / therapeutic use*
  • CD3 Complex / drug effects
  • CD4 Antigens / drug effects
  • Child
  • Child, Preschool
  • Female
  • Humans
  • Inosine Pranobex / administration & dosage
  • Inosine Pranobex / therapeutic use*
  • Male
  • Plant Preparations / therapeutic use
  • T-Lymphocytes / drug effects*
  • Treatment Outcome
  • Virus Diseases / drug therapy


  • Adjuvants, Immunologic
  • Antiviral Agents
  • CD3 Complex
  • CD4 Antigens
  • Plant Preparations
  • Inosine Pranobex