[Relationships between manufacturing parameters and pharmaceutical-technological requirements of biodegradable microparticles. 2. Preparation of injectable microparticles in biodegradable polyester]

Pharmazie. 1992 Feb;47(2):115-9.
[Article in German]


Local anesthetics containing biodegradable polyester microparticles are prepared using a modified solvent-evaporation process and a spray drying technique. The preparation methods are compared critically. The modified solvent-evaporation process is preferred for the preparation of microparticles. Yields of 90% and microparticle size distributions can be influenced in a reproducible manner. Using the spray drying technique yields are only 60%. The product is characterized by a high portion of microparticles under 10 microns, which are responsible for the rapid release of cinchocain in 168 h as well.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Anesthetics, Local
  • Biodegradation, Environmental
  • Chromatography, Gas
  • Drug Compounding
  • Microscopy, Electron, Scanning
  • Microspheres*
  • Particle Size
  • Polyesters
  • Spectrophotometry, Ultraviolet
  • Technology, Pharmaceutical


  • Anesthetics, Local
  • Polyesters