Animal models of cavitation in pulmonary tuberculosis

Tuberculosis (Edinb). 2006 Sep;86(5):337-48. doi: 10.1016/ Epub 2005 Dec 15.


Transmission of tuberculosis occurs with the highest frequency from patients with extensive, cavitary, pulmonary disease and positive sputum smear microscopy. In animal models of tuberculosis, the development of caseous necrosis is an important prerequisite for the formation of cavities although the immunological triggers for liquefaction are unknown. We review the relative merits and the information gleaned from the available animal models of pulmonary cavitation. Understanding the host-pathogen interaction important to the formation of cavities may lead to new strategies to prevent cavitation and thereby, block transmission.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Animals
  • Bronchoalveolar Lavage Fluid / microbiology
  • Cattle
  • Disease Models, Animal
  • Dogs
  • Elephants
  • Goats
  • Guinea Pigs
  • Haplorhini
  • Horses
  • Humans
  • Mice
  • Mycobacterium tuberculosis / isolation & purification*
  • Rabbits
  • Sheep
  • Swine
  • Tuberculosis, Pulmonary / microbiology*
  • Tuberculosis, Pulmonary / pathology*