PIDD: a switch hitter

Cell. 2005 Dec 16;123(6):980-2. doi: 10.1016/j.cell.2005.11.025.


In response to genotoxic stress, the PIDD protein promotes apoptosis downstream of the tumor-suppressor protein p53. In this issue of Cell, Janssens et al. (2005) demonstrate that, in response to such stress, PIDD forms a nuclear complex that enhances sumoylation of NEMO. This modification is important for the activation of the antiapoptotic transcription factor NF-kappaB.

Publication types

  • Comment

MeSH terms

  • Apoptosis / physiology*
  • Carrier Proteins / physiology*
  • Cell Nucleus / metabolism
  • Cytoplasm / metabolism
  • DNA Damage / physiology*
  • Death Domain Receptor Signaling Adaptor Proteins
  • Humans
  • I-kappa B Kinase / metabolism
  • Models, Biological
  • NF-kappa B / metabolism
  • SUMO-1 Protein / metabolism
  • Signal Transduction


  • Carrier Proteins
  • Death Domain Receptor Signaling Adaptor Proteins
  • IKBKG protein, human
  • NF-kappa B
  • PIDD1 protein, human
  • SUMO-1 Protein
  • I-kappa B Kinase