DNA sliding clamps: just the right twist to load onto DNA

Curr Biol. 2005 Dec 20;15(24):R989-92. doi: 10.1016/j.cub.2005.11.047.


Two recent papers illuminate a key step in DNA sliding clamp loading: one reveals the structure of the PCNA clamp wrapped around DNA--still open from being loaded--while the other finds that the clamp may assist this process by forming a right-handed helix upon opening.

Publication types

  • Review

MeSH terms

  • DNA / metabolism*
  • DNA Replication / genetics
  • DNA Replication / physiology*
  • DNA-Binding Proteins / metabolism*
  • DNA-Directed DNA Polymerase / chemistry
  • DNA-Directed DNA Polymerase / metabolism*
  • Models, Molecular*
  • Proliferating Cell Nuclear Antigen / metabolism
  • Replication Protein C / metabolism


  • DNA-Binding Proteins
  • Proliferating Cell Nuclear Antigen
  • DNA
  • DNA-Directed DNA Polymerase
  • Replication Protein C