Abstract
Two recent papers illuminate a key step in DNA sliding clamp loading: one reveals the structure of the PCNA clamp wrapped around DNA--still open from being loaded--while the other finds that the clamp may assist this process by forming a right-handed helix upon opening.
MeSH terms
-
DNA / metabolism*
-
DNA Replication / genetics
-
DNA Replication / physiology*
-
DNA-Binding Proteins / metabolism*
-
DNA-Directed DNA Polymerase / chemistry
-
DNA-Directed DNA Polymerase / metabolism*
-
Models, Molecular*
-
Proliferating Cell Nuclear Antigen / metabolism
-
Replication Protein C / metabolism
Substances
-
DNA-Binding Proteins
-
Proliferating Cell Nuclear Antigen
-
DNA
-
DNA-Directed DNA Polymerase
-
Replication Protein C