External beam radiotherapy for differentiated thyroid cancer

Am J Otolaryngol. 2006 Jan-Feb;27(1):24-8. doi: 10.1016/j.amjoto.2005.05.017.


Purpose: To evaluate the efficacy of external beam radiation therapy (EBRT) for differentiated thyroid carcinomas.

Methods: Forty-two patients with a locally advanced or recurrent differentiated thyroid carcinoma received high-dose EBRT. Thirty-three patients had local-regional disease and 9 patients also had asymptomatic disease metastases. Twenty patients (48%) had macroscopic local-regional disease before EBRT.

Results: The 5-year outcomes for the overall population and for the subset of those without distant metastases before EBRT were local-regional control (88% and 89%, respectively), cause-specific survival (80% and 86%, respectively), and overall survival (54% and 60%, respectively). Local-regional control was improved for patients with microscopic residual disease compared with macroscopic disease, those with previously untreated tumors, and for those who received more than 64 Gy.

Conclusion: EBRT increases the likelihood of local-regional control for patients with locally advanced differentiated thyroid carcinoma.

Publication types

  • Comparative Study

MeSH terms

  • Adult
  • Aged
  • Biopsy, Needle
  • Brachytherapy*
  • Carcinoma, Papillary, Follicular / mortality
  • Carcinoma, Papillary, Follicular / pathology*
  • Carcinoma, Papillary, Follicular / radiotherapy*
  • Carcinoma, Papillary, Follicular / surgery
  • Cohort Studies
  • Female
  • Humans
  • Immunohistochemistry
  • Male
  • Middle Aged
  • Neoplasm Invasiveness / pathology
  • Neoplasm Staging
  • Prognosis
  • Radiotherapy, Adjuvant
  • Retrospective Studies
  • Risk Assessment
  • Survival Rate
  • Thyroid Neoplasms / mortality
  • Thyroid Neoplasms / pathology*
  • Thyroid Neoplasms / radiotherapy*
  • Thyroid Neoplasms / surgery
  • Thyroidectomy / methods
  • Treatment Outcome