Molecular Mechanisms of Dendritic Spine Morphogenesis

Curr Opin Neurobiol. 2006 Feb;16(1):95-101. doi: 10.1016/j.conb.2005.12.001. Epub 2005 Dec 19.

Abstract

Excitatory synapses are formed on dendritic spines, postsynaptic structures that change during development and in response to synaptic activity. Once mature, however, spines can remain stable for many months. The molecular mechanisms that control the formation and elimination, motility and stability, and size and shape of dendritic spines are being revealed. Multiple signaling pathways, particularly those involving Rho and Ras family small GTPases, converge on the actin cytoskeleton to regulate spine morphology and dynamics bidirectionally. Numerous cell surface receptors, scaffold proteins and actin binding proteins are concentrated in spines and engaged in spine morphogenesis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Dendrites / physiology*
  • Dendrites / ultrastructure*
  • Models, Neurological
  • Morphogenesis
  • Neuronal Plasticity
  • Nuclear Matrix-Associated Proteins / physiology

Substances

  • Nuclear Matrix-Associated Proteins