Kainate receptor physiology

Curr Opin Pharmacol. 2006 Feb;6(1):89-97. doi: 10.1016/j.coph.2005.08.004. Epub 2005 Dec 19.

Abstract

Glutamate receptors constitute a complex signalling system at most of the excitatory synapses in the brain. Of the known ionotropic glutamate receptors, kainate receptors are ubiquitous in the central nervous system, and a considerable amount of data indicates that this class of receptors is present at both sides of the synapse. Pre- and postsynaptic kainate receptors are able to regulate both transmission of information and excitability in a synapse-specific manner. Proteins interacting with kainate receptor subunits are being identified and functional studies have provided evidence of the existence of a dual signalling system. It has become clear that these receptors have a role in synaptic plasticity and that they might also have a fundamental role in epilepsy through the strategic control of network excitability. However, the role of kainate receptors in other brain pathologies remains obscure.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Anticonvulsants / pharmacology
  • Anticonvulsants / therapeutic use
  • Brain / drug effects
  • Brain / metabolism
  • Epilepsy / drug therapy
  • Epilepsy / metabolism
  • Humans
  • Neuronal Plasticity
  • Protein Transport
  • Receptors, Kainic Acid / antagonists & inhibitors
  • Receptors, Kainic Acid / metabolism*
  • Signal Transduction
  • Synaptic Transmission

Substances

  • Anticonvulsants
  • Gluk1 kainate receptor
  • Gluk2 kainate receptor
  • Receptors, Kainic Acid