A cancer DNA phenotype in healthy prostates, conserved in tumors and adjacent normal cells, implies a relationship to carcinogenesis

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):19093-6. doi: 10.1073/pnas.0509630102. Epub 2005 Dec 16.

Abstract

A cancer DNA phenotype, identical to the DNA structure of tumors, has been identified in the prostate glands of certain healthy men over 55 years of age. We now show that the same DNA signature exists in normal tissues adjacent to tumors. This finding implies that the phenotype is maintained in normal prostate cells from its inception through tumor development. The presence of the phenotype in tumors, adjacent normal cells, and in the normal prostate cells of certain older men suggests that it is a potentially critical factor in tumor development and may serve as an early biomarker for cancer risk assessment. Intervention to inhibit the development of the phenotype in healthy men, or to eliminate it once formed, may suppress or even prevent tumor formation.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Biomarkers, Tumor
  • Carcinogens
  • DNA / chemistry
  • DNA, Neoplasm*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Metastasis
  • Phenotype
  • Prostate / metabolism*
  • Prostate / pathology
  • Prostatic Neoplasms / genetics*
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / prevention & control
  • Risk
  • Spectrophotometry
  • Spectroscopy, Fourier Transform Infrared

Substances

  • Biomarkers, Tumor
  • Carcinogens
  • DNA, Neoplasm
  • DNA