Lack of association between infection with a novel human coronavirus (HCoV), HCoV-NH, and Kawasaki disease in Taiwan

J Infect Dis. 2006 Jan 15;193(2):283-6. doi: 10.1086/498875. Epub 2005 Dec 2.


We investigated whether infection with a novel human coronavirus (HCoV), called "New Haven coronavirus" (HCoV-NH)--which is similar to and likely represents the same species as another novel HCoV, HCoV-NL63--is associated with Kawasaki disease (KD) in Taiwan. Fifty-three patients with KD were enrolled in our study. Serum, peripheral-blood mononuclear cells, nasopharyngeal aspirates, throat swabs, and rectal swabs from these patients were assayed for HCoV-NL63 by real-time reverse-transcriptase (RT) polymerase chain reaction (PCR), and the throat swabs, nasopharyngeal aspirates, and rectal swabs were also assayed for HCoV-NH by RT-PCR. All PCR results were negative for both HCoV-NL63 and HCoV-NH; therefore, we did not find any association between HCoV-NH infection and KD in Taiwan.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Child, Preschool
  • Coronavirus / genetics
  • Coronavirus / isolation & purification*
  • Coronavirus Infections / complications*
  • Female
  • Humans
  • Infant
  • Leukocytes, Mononuclear / virology
  • Male
  • Mucocutaneous Lymph Node Syndrome / etiology*
  • Mucocutaneous Lymph Node Syndrome / virology
  • Nasopharynx / virology
  • Pharynx / virology
  • RNA, Viral / analysis
  • Rectum / virology
  • Reverse Transcriptase Polymerase Chain Reaction
  • Serum / virology
  • Taiwan


  • RNA, Viral