Use of alendronate in the treatment of vitamin D intoxication in infants

Turk J Pediatr. Oct-Dec 2005;47(4):373-5.


Vitamin D intoxication remains a challenging problem due to lack of an efficient treatment. Bisphosphonates, inhibitors of osteoclast-mediated bone resorption, however, have been proposed as a safe and effective alternative in the treatment of vitamin D intoxication. We present here two infants with vitamin D intoxication who were successfully treated with alendronate. We propose that oral alendronate is an alternative to intravenous bisphosphonates in the treatment of vitamin D intoxication in infancy.

Publication types

  • Case Reports

MeSH terms

  • Alendronate / therapeutic use*
  • Bone Density Conservation Agents / therapeutic use*
  • Calcium / blood
  • Female
  • Humans
  • Infant
  • Vitamin D / toxicity*


  • Bone Density Conservation Agents
  • Vitamin D
  • Calcium
  • Alendronate