Activation of pannexin 1 channels by ATP through P2Y receptors and by cytoplasmic calcium

FEBS Lett. 2006 Jan 9;580(1):239-44. doi: 10.1016/j.febslet.2005.12.004. Epub 2005 Dec 12.


The ability for long-range communication through intercellular calcium waves is inherent to cells of many tissues. A dual propagation mode for these waves includes passage of IP3 through gap junctions as well as an extracellular pathway involving ATP. The wave can be regenerative and include ATP-induced ATP release via an unknown mechanism. Here, we show that pannexin 1 channels can be activated by extracellular ATP acting through purinergic receptors of the P2Y group as well as by cytoplasmic calcium. Based on its properties, including ATP permeability, pannexin 1 may be involved in both initiation and propagation of calcium waves.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Adenosine Triphosphate / pharmacology*
  • Animals
  • Calcium / metabolism*
  • Calcium Signaling / drug effects*
  • Cell Membrane Permeability / drug effects
  • Connexins / genetics
  • Connexins / metabolism*
  • Female
  • Humans
  • Inositol Phosphates / metabolism
  • Membrane Potentials / drug effects
  • Nerve Tissue Proteins
  • Oocytes
  • Receptors, Purinergic P2 / genetics
  • Receptors, Purinergic P2 / metabolism*
  • Receptors, Purinergic P2Y1
  • Xenopus


  • Connexins
  • Inositol Phosphates
  • Nerve Tissue Proteins
  • P2RY1 protein, human
  • PANX1 protein, human
  • Receptors, Purinergic P2
  • Receptors, Purinergic P2Y1
  • Adenosine Triphosphate
  • Calcium