How antibodies act as natural adjuvants

Immunol Lett. 2006 Apr 15;104(1-2):38-45. doi: 10.1016/j.imlet.2005.11.005. Epub 2005 Dec 1.


Antibodies can act like adjuvants. They can potently enhance the antibody response, and in the case of IgG and IgE also the T cell response, to the very antigen they are specific for. In this review we will discuss the recent advances made in our understanding of the underlying mechanisms of antibody-mediated feedback enhancement. The immuno-stimulatory properties of IgM, IgG1, IgG2a, IgG2b, IgG3 and IgE will be reviewed in relationship to the complement system and Fc receptors and the physiological relevance will be discussed.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Adjuvants, Immunologic / pharmacology*
  • Animals
  • Antibodies / pharmacology*
  • Antibody Formation / drug effects*
  • Antibody Formation / immunology
  • Antigens / immunology*
  • Humans
  • Immunoglobulins / pharmacology*
  • Mice


  • Adjuvants, Immunologic
  • Antibodies
  • Antigens
  • Immunoglobulins