Does Helicobacter pylori have a pathogenic role in bronchiectasis?

Respir Med. 2006 Jul;100(7):1202-7. doi: 10.1016/j.rmed.2005.10.021. Epub 2005 Dec 20.


Aim: To investigate the presence of Helicobacter pylori (H. pylori) in bronchial biopsies of patients with bronchiectasis, by histochemical and immunochemical staining.

Setting: 800-bed tertiary university hospital.

Methods: Observational study.

Patients: forty-six patients with bronchiectasis in a stable clinical condition and 8 control patients.

Interventions: Serum samples determination of IgG levels for H. pylori by ELISA. Immunostaining with an anti-H. pylori antibody (NCL-HPp, Novocastra) of bronchial mucosa obtained by fiberoptic bronchoscopy from both patients with bronchiectasis and controls.

Results: Twenty-one out of 46 patients with bronchiectasis (46%) had positive serology for H. pylori. We obtained 40 bronchial biopsies in patients with bronchiectasis and 8 bronchial biopsies in control patients. No evidence of H. pylori was obtained in the bronchial samples of both patients and controls.

Conclusions: The results of our study could not demonstrate the presence of H. pylori in bronchial specimens from patients with bronchiectasis.

MeSH terms

  • Adult
  • Aged
  • Antibodies, Bacterial / blood
  • Biopsy
  • Bronchi / microbiology
  • Bronchi / pathology
  • Bronchiectasis / microbiology*
  • Bronchiectasis / physiopathology
  • Female
  • Forced Expiratory Volume
  • Helicobacter Infections / complications*
  • Helicobacter pylori / immunology
  • Helicobacter pylori / isolation & purification*
  • Humans
  • Immunoglobulin G / blood
  • Male
  • Middle Aged
  • Prospective Studies
  • Vital Capacity


  • Antibodies, Bacterial
  • Immunoglobulin G