Chaperone-related immune dysfunction: an emergent property of distorted chaperone networks

Trends Immunol. 2006 Feb;27(2):74-9. doi: 10.1016/ Epub 2005 Dec 20.


Molecular chaperones (heat shock proteins) are important components of cellular networks, such as protein-protein and gene regulatory networks. Chaperones participate in the folding of immunologically important proteins, presentation of antigens and activation of the immune system. Here, we propose that chaperone-related immune dysfunction might be more general than was previously thought. Mutations and polymorphism of chaperones and the regulators of their synthesis, heat shock factor-1, chaperone diseases, sick chaperones and chaperone overload might all affect (mostly impairing) immune responses.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Humans
  • Molecular Chaperones / genetics
  • Molecular Chaperones / immunology*
  • Molecular Chaperones / metabolism*
  • Mutation / genetics
  • Polymorphism, Genetic / genetics
  • Protein Binding


  • Molecular Chaperones