Resection and primary anastomosis is a valid surgical option for infants with necrotizing enterocolitis who weigh less than 1000 g

Arch Surg. 2005 Dec;140(12):1149-51. doi: 10.1001/archsurg.140.12.1149.


Hypothesis: Primary anastomosis following intestinal resection is a valid surgical option in the treatment of infants with necrotizing enterocolitis (NEC) who weigh less than 1000 g.

Design: Retrospective case series.

Setting: Tertiary neonatal surgery referral center.

Patients: All infants with confirmed NEC weighing less than 1000 g admitted to our intensive care unit over 4 years.

Intervention: For infants requiring laparotomy and intestinal resection, primary anastomosis was performed whenever the clinical condition permitted.

Main outcome measures: Short- and long-term survival, length of intensive care unit stay, and complications.

Results: Fifty-one infants with NEC who weighed less than 1000 g were admitted during the study period. Twelve infants underwent intestinal resection and primary anastomosis (median weight at surgery, 0.83 kg; range, 0.6-0.96 kg). One infant developed recurrent NEC, requiring further surgery, but there were no anastomotic leakages and no strictures. The median postoperative stay on our intensive care unit was 14 days (range, 2-49 days). All 12 infants survived their episode of acute NEC, and 8 are alive, with a median follow-up of 34.2 months (range, 4.7-48.4 months). Only 1 death was related to NEC. During the same period, 14 infants underwent intestinal resection and stoma formation. Ten survived the acute episode, and 6 are alive at a median follow-up of 24.0 months (range, 13.1-33.9 months). The median postoperative intensive care unit stay was 18 days (range, 2-74 days). Necrotizing enterocolitis-related complications occurred in 8 of these infants.

Conclusions: The outcome of infants with NEC who weigh less than 1000 g and undergo primary anastomosis is comparable to that of infants treated using alternative techniques. It is, therefore, a valid surgical option in selected infants. The mortality in this group of infants is high.

MeSH terms

  • Anastomosis, Surgical / methods*
  • Enterocolitis, Necrotizing / surgery*
  • Female
  • Humans
  • Infant
  • Infant, Newborn
  • Infant, Very Low Birth Weight*
  • Length of Stay / statistics & numerical data
  • Male
  • Postoperative Complications
  • Recurrence
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome