Targeted UV-B phototherapy for plaque-type psoriasis

Arch Dermatol. 2005 Dec;141(12):1542-6. doi: 10.1001/archderm.141.12.1542.


Objective: To determine whether targeted UV-B phototherapy is efficacious and safe in the treatment of localized psoriasis and whether there is a dose-response relationship.

Design: Randomized, evaluator-blind, controlled study.

Setting: Dermatology clinic in a large university-based hospital in Bangkok, Thailand.

Patients: Fourteen patients with stable, localized, plaque-type psoriasis.

Interventions: Patients were randomized to receive different fluences of targeted UV-B phototherapy 3 times weekly based on predetermined minimal erythema doses (MEDs). Treatment fluences were constant throughout the study period of 4 weeks. Follow-up was carried out until lesions returned to original state.

Main outcome measures: Modified psoriasis area and severity index.

Results: All fluences of UV-B produced some clinical improvement and were very well tolerated. Fluences ranging from 1 to 6 multiples of MEDs resulted in clearance of lesions in some patients with 6 MEDs producing clearance in 77% of patients. The number of treatments required to clear psoriatic lesions when 2 to 6 MEDs were used was 5.0 to 6.1 treatments. The only adverse events observed were erythema, which was asymptomatic in most subjects, and hyperpigmentation.

Conclusions: Incoherent, targeted UV-B phototherapy is a safe and efficacious treatment modality for localized psoriasis. Its value in other UV-B responsive conditions should be further investigated.

Publication types

  • Clinical Trial
  • Randomized Controlled Trial

MeSH terms

  • Adult
  • Female
  • Hospitals, University
  • Humans
  • Male
  • Middle Aged
  • Phototherapy / methods*
  • Psoriasis / pathology*
  • Psoriasis / therapy*
  • Severity of Illness Index
  • Single-Blind Method
  • Thailand
  • Treatment Outcome
  • Ultraviolet Therapy