The mitochondrial theory of aging and its relationship to reactive oxygen species damage and somatic mtDNA mutations

Proc Natl Acad Sci U S A. 2005 Dec 27;102(52):18769-70. doi: 10.1073/pnas.0509776102. Epub 2005 Dec 19.
No abstract available

Publication types

  • Comment

MeSH terms

  • Adenosine Triphosphate / metabolism
  • Aging / physiology*
  • Animals
  • Apoptosis
  • Bacteria
  • Cellular Senescence
  • DNA Damage
  • DNA Polymerase gamma
  • DNA, Mitochondrial / genetics*
  • DNA-Directed DNA Polymerase / metabolism
  • Free Radicals
  • Humans
  • Mice
  • Mitochondria / pathology*
  • Models, Biological
  • Mutation
  • Phenotype
  • Reactive Oxygen Species*

Substances

  • DNA, Mitochondrial
  • Free Radicals
  • Reactive Oxygen Species
  • Adenosine Triphosphate
  • DNA Polymerase gamma
  • DNA-Directed DNA Polymerase