pH-sensitive vesicles based on a biocompatible zwitterionic diblock copolymer

J Am Chem Soc. 2005 Dec 28;127(51):17982-3. doi: 10.1021/ja056514l.


Highly biocompatible pH-sensitive diblock copolymer vesicles were prepared from the self-assembly of a biocompatible zwitterionic copolymer, poly[2-(methacryloyloxy)ethyl phosphorylcholine-block-2-(diisopropylamino)ethyl methacrylate], PMPC-b-PDPA. Vesicle formation occurred spontaneously by adjusting the solution pH from pH 2 to above 6, with the hydrophobic PDPA chains forming the vesicle walls. Transmission electron microscopy (TEM), dynamic laser light scattering (DLS), and UV-visible absorption spectrophotometry were used to characterize these vesicles. Gold nanoparticle-decorated vesicles were also obtained by treating the vesicles with HAuCl4, followed by NaBH4.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biocompatible Materials / chemistry*
  • Hydrogen-Ion Concentration
  • Hydrophobic and Hydrophilic Interactions
  • Methacrylates / chemistry*
  • Phosphorylcholine / analogs & derivatives*
  • Phosphorylcholine / chemistry
  • Polymethacrylic Acids / chemistry*


  • Biocompatible Materials
  • Methacrylates
  • Polymethacrylic Acids
  • poly(2-methacryloyloxyethyl-phosphorylcholine)
  • Phosphorylcholine
  • polymethacrylic acid
  • 2-methacryloyloxyethyl phosphorylcholine