Microarray technology in the investigation of diseases of myocardium with special reference to infection

Front Biosci. 2006 May 1;11:1802-13. doi: 10.2741/1924.

Abstract

Microarrays are now routinely employed to characterize gene expression of thousands of genes from a single hybridization. The genome wide gene expression profile aids in the understanding of genes that may be regulated in a particular pathological condition. This paper provides an overview of microarray technology and its recent developments followed by its usage in studies of cardiovascular disease and how it pertains to viral and parasitic infections of the heart.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Aortic Aneurysm / pathology
  • Cardiomegaly / pathology
  • Cardiomyopathies
  • Cardiovascular Diseases / pathology
  • Chagas Disease / pathology
  • DNA Primers / chemistry
  • DNA, Complementary / metabolism
  • Gene Expression Regulation*
  • Heart / parasitology
  • Heart / virology
  • Humans
  • Hypertension / pathology
  • Hypertrophy
  • Image Processing, Computer-Assisted
  • Infections*
  • Inflammation
  • Microscopy, Confocal
  • Myocardial Ischemia / pathology
  • Myocardium / pathology*
  • Nucleic Acid Hybridization
  • Oligonucleotide Array Sequence Analysis / methods*
  • Oligonucleotide Probes / chemistry
  • Reactive Oxygen Species
  • Reverse Transcriptase Polymerase Chain Reaction
  • Stress, Mechanical

Substances

  • DNA Primers
  • DNA, Complementary
  • Oligonucleotide Probes
  • Reactive Oxygen Species