Abstract
CD8+ T cells have a protective role in experimental visceral leishmaniasis. However, the observation that inflammatory cytokines induce bystander activation of CD8+ T cells questions the need for antigen-dependent effector function. Here, we demonstrate that successful adoptive immunotherapy with CD8+ T cells is strictly dependent upon the presence of cognate antigen.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antigens, Protozoan / immunology*
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CD8-Positive T-Lymphocytes / immunology*
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Immunotherapy, Adoptive*
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Leishmania donovani / genetics
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Leishmania donovani / immunology*
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Leishmaniasis, Visceral / immunology*
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Leishmaniasis, Visceral / therapy*
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Mice
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Mice, Transgenic
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Ovalbumin / biosynthesis
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Ovalbumin / genetics
Substances
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Antigens, Protozoan
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Ovalbumin