Abstract
Recent studies have focused on establishing a link between the pathogenesis of ethanol and the disruption of metabolic pathways in the liver. Ethanol alters hepatic methionine metabolism, leading to perturbation of S-adenosylmethionine-dependent transmethylation. Therefore, the supply of metabolically related nutrients such as folate may play a role in the hepatotoxic effects of ethanol.
MeSH terms
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Animals
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Central Nervous System Depressants / adverse effects
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Central Nervous System Depressants / pharmacology*
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Ethanol / adverse effects
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Ethanol / pharmacology*
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Folic Acid / drug effects
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Folic Acid / metabolism*
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Folic Acid Deficiency / metabolism
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Homocysteine / drug effects
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Homocysteine / metabolism*
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Humans
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Liver / drug effects
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Liver / injuries
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Liver / metabolism*
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Methionine / drug effects
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Methionine / metabolism*
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Rats
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Swine
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Swine, Miniature
Substances
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Central Nervous System Depressants
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Homocysteine
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Ethanol
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Folic Acid
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Methionine